Closing the Loop by Operationalizing Systems Engineering and Design (CLOSED)
Motivation:
Specific Aims :
Aim 1:Use systems engineering and patient engagement to design, develop, and refine a highly reliable “closed loop” system for diagnostic tests and referrals that ensures diagnostic orders and follow-up occur reliably within clinically- and patient-important time-frames.
Aim 2: Use systems engineering and patient engagement to design, develop, and refine a highly reliable “closed loop” system for symptoms that ensures clinicians receive and act on feedback about evolving symptoms and physical findings of concern to patients or clinicians.
Aim 3: Design for generalizability across health systems more broadly so that the processes created in Aims 1 and 2 are effective in (1) a practice in an underserved community, (2) a large tele-medicine system, and (3) a representative range of simulated other health system settings and populations.
Partners:
Sunday, June 2, 2019
Sunday, June 2, 2019
Approach:
Sunday, June 2, 2019
Results to Date:
Iulian Ilies, PhD

Iulian is a Research Scientist with interests and expertise in the broader area of exploratory data analysis. He has received his interdisciplinary education in mathematics, statistics, computer science and cognitive psychology from Jacobs University in Bremen, Germany, and has over 10 years of research experience in applied and computational statistics, mathematical modeling, and operations research. At HSyE, he is the technical lead on the surgical site infections and opioid epidemic modeling projects, provides predictive analytics support for other projects as needs arise, and is exploring the incidence and impact of multimodality on healthcare duration data. His previous work includes cluster analysis and classification of high-dimensional data, time series analysis and forecasting, image segmentation and reconstruction, modeling of nonlinear growth processes, and applications of general linear models and correlation analysis. When not working, Iulian enjoys hiking, exploring the nature preserves of the greater Boston area, reading fantasy fiction, occasionally drawing, or simply keeping up to date with the latest topics in science and technology.
Email: i.ilies@neu.edu
Joined HSyE: April 2015
Hometown: Piatra Neamţ, Romania
Education: PhD, Statistics, Jacobs University Bremen, 2010; MSc, Mathematics, Jacobs University Bremen, 2007; BSc, Mathematics and Integrated Social and Cognitive Psychology, International University Bremen, 2006
Dissertation: Cluster Analysis for Large, High-Dimensional Datasets: Methodology and Applications
Research Interests: data mining, machine learning, applied and computational statistics, statistical process control, spread and growth models
Hobbies: hiking, reading, drawing
Project Involvement at HSyE
Duke surgical site infections – all sub-projects
EAGER opioid epidemic – ODE and AB models
PSLL – system of systems sub-project
EHRLL – Boston Children’s sub-project
Publications
-
Baker, A.W., Haridy, S., Salem, J., Ilies, I., Ergai, A.O., Samareh, A., Andrianas, N., Benneyan, J.C., Sexton, D.J., Anderson, D.J. (2018). Performance of statistical process control methods for regional surgical site infection surveillance: a 10-year multicentre pilot study. British Medical Journal of Quality and Safety.
-
Ilies, I., Sipahi, R., & Zupanc, G.K.H. (2018). Growth of adult spinal cord in knifefish: Development and parametrization of a distributed model. Journal of Theoretical Biology, 437, 101-114.
-
Benneyan, J.C., Garrahan, J., Ilies, I., & Duan, X. (2017). Modeling approaches, challenges, and preliminary results for the opioid and heroin co-epidemic crisis. Winter Simulation Conference, Las Vegas, NV.
-
Gordon, D.G., Ilies, I., & Traniello, J.F.A. (2017). Behavior, brain, and morphology in a complex insect society: trait integration and social evolution in the exceptionally polymorphic ant Pheidole rhea. Behavioral Ecology and Sociobiology, 71, 166.
-
Ilies, I., Anderson, D.J., Jacobsen, M.M., Salem, J., Baker, A.W., & Benneyan, J.C. (2017). Retrospective optimization of statistical process control (SPC) charts to detect clinically-relevant increases in surgical site infection (SSI) rates. ID Week, San Diego, CA.
-
Sîrbulescu, R.F., Boehm, C.K., Soon, E., Wilks, M.Q., Ilies, I., Yuan, H., Maxner, B., Chronos, N., Kaittanis, C., Normandin, M.D. El Fakhri, G., Orgill, D.P., Sluder, A.E., & Poznansky, M.C. (2017). Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions. Wound Repair and Regeneration, 25, 774-791.
-
Sîrbulescu, R.F., Ilies, I., Meyer, A., & Zupanc, G.K.H. (2017). Additive neurogenesis supported by multiple stem cell populations mediates adult spinal cord development: a spatio‐temporal statistical mapping analysis in a teleost model of indeterminate growth. Developmental Neurobiology, 77, 1269–1307.
-
Vitalo A.G., Sîrbulescu, R.F., Ilies, I., & Zupanc, G.K.H. (2016). Absence of gliosis in a teleost model of spinal cord regeneration. Journal of Comparative Physiology A, 202, 445-456.
-
Ilies, I., Muscedere, M.L., & Traniello, J.F.A. (2015). Morphology and neuroanatomical trait clusters in the ant genus Pheidole: modularity and integration in brain evolution. Brain, Behavior and Evolution, 85, 63-76.
-
Sîrbulescu, R.F., Ilies, I., Vitalo, A.G., Trull, K., Zhu, J., Traniello, I.M., & Zupanc, G.K.H. (2015). Adult stem cells in the knifefish cerebellum. Developmental Neurobiology, 75, 39-65.
-
Sîrbulescu, R.F., Ilies, I., Zupanc, G.K.H. (2015). Matrix metalloproteinase-2 and -9 in the cerebellum of teleost fish: functional implications for adult neurogenesis. Molecular and Cellular Neuroscience, 68, 9-23.
-
Ilies, I., Sîrbulescu, R.F., & Zupanc, G.K.H. (2014). Indeterminate body growth and lack of gonadal decline in the brown ghost knifefish (Apteronotus leptorhynchus), an organism exhibiting negligible brain senescence. Canadian Journal of Zoology, 92, 947-953.
-
Sîrbulescu, R.F., Ilies, I., & Zupanc, G.K.H. (2014). Quantitative analysis reveals dominance of gliogenesis over neurogenesis in an adult brainstem oscillator. Developmental Neurobiology, 74, 934-952.
-
Zupanc, G.K.H., Ilies, I., Sîrbulescu, R.F., & Zupanc, M.M. (2014). Large-scale identification of proteins involved in the development of a sexually dimorphic behavior. Journal of Neurophysiology, 111, 1646-1654.
-
Ilies, I., Traniello, I.M., Sîrbulescu, R.F., & Zupanc, G.K.H. (2014). Determination of relative age using growth increments of scales as a minimally invasive method in the tropical freshwater Apteronotus leptorhynchus. Journal of Fish Biology, 84, 1312-1325.
-
Traniello, I.M., Sîrbulescu, R.F., Ilies, I., & Zupanc, G.K.H. (2014). Age-related changes in stem cell dynamics, neurogenesis, apoptosis, and gliosis in the adult brain: a novel teleost fish model of negligible senescence. Developmental Neurobiology, 74, 514-530.
-
Ilies, I., Zupanc, M.M., & Zupanc, G.K.H. (2012). Proteome analysis reveals protein candidates involved in early stages of brain regeneration in teleost fish. Neuroscience, 219, 302-313.
-
Zupanc, G.K.H., Sîrbulescu, R.F., & Ilies, I. (2012). Radial glia in the cerebellum of adult teleost fish: Implications for the guidance of migrating new neurons. Neuroscience, 210, 416-430.
-
Ilies, I., & Jacobs, A. (2011). Automatic image annotation through concept propagation. In P. Ludes (Ed.), Algorithms of Power – Key Invisibles (pp. 71-86). Münster, Germany: LIT Verlag.
-
Ilies, I., Jacobs, A., Herzog, O., & Wilhelm, A. (2010). Combining text and image processing in an automated image classification system. 41st Symposium on the Interface, Seattle, WA.
-
Ilies, I., & Wilhelm, A. (2010). Projection-based partitioning for large, high-dimensional datasets. Journal of Computational and Graphical Statistics, 19, 474-492.
-
Sîrbulescu, R.F., Ilies, I., & Zupanc, G.K.H. (2009). Structural and functional regeneration after spinal cord injury in the weakly electric teleost fish, Apteronotus leptorhynchus. Journal of Comparative Physiology A, 195, 699-714.
-
Ilies, I., Jacobs, A., Wilhelm, A., & Herzog, O. (2009). Classification of news images using captions and a visual vocabulary [Technical Report No. 50]. Bremen, Germany: Technologie Zentrum-Informatik, Universität Bremen.
-
Jacobs, A., Herzog, O., Wilhelm, A., & Ilies, I. (2008). Relaxation-based data mining on images and text from news web sites. 4th World Conference of the IASC, Yokohama, Japan.
-
Ilies, I., Jaeger, H., Kosuchinas, O., Rincon, M., Sakenas, V., & Vaskevicius, N. (2007). Stepping forward through echoes of the past: forecasting with echo state networks. [Report submitted to the NN3 2006/2007 Forecasting Competition]. Bremen, Germany: School of Engineering and Science, Jacobs University Bremen.
-
Zupanc, G.K.H., Sîrbulescu, R.F., Nichols, A., & Ilies, I. (2006). Electric interactions through chirping behavior in the weakly electric fish, Apteronotus leptorhynchus. Journal of Comparative Physiology A, 192, 159-173.